Northern Illinois comes in as heavy underdogs against Florida State, owners of an 11-2 record and the Atlantic Coast Conference champions.
Oddsmakers have made the Huskies a 13-point underdog against the Seminoles, one of the largest lines in recent Orange Bowl history.
But the Orange Bowl has had its share of upsets. Here's a look at five of them over the past 25 years.
1988: Miami (FL) 20, Oklahoma 14The line: Oklahoma -3Recap: Miami won its second national championship in five years. Michael Irvin's 23-yard touchdown catch put the Hurricanes up by 10 in the third quarter as Jimmy Johnson's Miami squad outplayed Barry Switzer and the Sooners.
2001: Oklahoma 13, Florida St. 2The line: Florida St. -11Recap: Oklahoma's defense dominated a Florida State team that led the nation in total offense. The Seminoles only score came on a safety as a result of a bad long snap in the final minute. The win gave Oklahoma the national championship.
2008: Kansas 24, Virginia Tech 21The line: Virginia Tech -3Recap: The Jayhawk defense recorded three interceptions on the night, including a 60-yard interception return for a touchdown by Aqib Talib. Kansas QB Todd Reesing scored on a two-yard touchdown run to clinch the win for Kansas.
2010: Iowa 24, Georgia Tech 14The line: Georgia Tech -6Recap: Iowa's defense solved Georgia Tech's triple-option offense as Adrian Clayborn recorded two sacks and nine tackles in the win. Iowa QB Ricky Stanzi threw two touchdowns in the first quarter and RB Brandon Wegher's 32-yard touchdown run sealed the win for the Hawkeyes.
2012: West Virginia 70, Clemson 33The line: Clemson -3Recap: Led by Geno Smith's six touchdown passes, West Virginia set an all-time bowl record with 70 points in the blowout win. The Mountaineers scored 35 points in the second quarter alone and led, 49-20, at halftime.